TwitterACicon86x90vert facebookACicon86x90vert
TV/Radio XFINITY | WOW! | WBBM | WXRT | B96 + Dance | US99 | the Drive 97.1

YoutubeTwitterFacebookArlingtoncardinalYahoo! Google Bing Aol.ArlingtoncardinalTMZ Rotten Tomatoes ET Online Box Office MojoArlingtoncardinal Channel 9 WGN Channel 7 Chicago ABC Channel 5 Chicago NBC Channel 2 Chicago CBS Daily HeraldChicago Tribune Breaking NewsArlingtoncardinal Chicago Gas THE GUIDE

Valsartan Meds Recalled by Teva Pharmaceuticals for Possible Contamination

Mon December 03 2018 5:16 am
Share The Cardinal -- Articles (E-Mail, Facebook, Twitter & More) 

CHICAGO BEARS RADIO -- WBBM Newsradio 780 "Traffic on the 8's"

The United States Food and Drug Administration (FDA) on Tuesday, November 27, 2018 updated its blood pressure drug recall list to warn hypertension patients and consumers of another voluntary valsartan blood pressure medication recall.

Teva Pharmaceuticals issued another voluntary recall for valsartan combination tablets manufactured by Mylan India, including amlodipine-valsartan combination tablets and amlodipine-valsartan-hydrochlorothiazide combination tablets.

The drugs are being recalled due to the possibility that they are contaminated with organic chemical N-nitrosodiethylamine (NDEA), which (of all things) is used to make liquid rocket fuel and is classified as a probable human carcinogen. NEDA is also typically found in very small amounts in certain foods, drinking water, air pollution, and certain industrial processes.

As of this recall, Teva has now pulled back all of its valsartan drugs on the U.S. market. These ongoing 2018 blood pressure recalls began back on July 13 2018 when three drug companies, including Teva Pharmaceuticals, began recalling medications containing valsartan.

Other blood pressure drugs have been recalled over concerns they also contain trace amounts of NDEA. In early November 2018, another blood pressure drug, irbesartan, was recalled. Next in mid-November 2018 a voluntary recall of losartan potassium hydrochlorothiazide tablets, which are also prescribed to treat hypertension.

The FDA warned that the risk to health may be higher if patients suddenly stop taking any blood pressure medication. As with the other valsartan blood pressure medications recalled, patients taking Amlodipine / Valsartan combination tablets or Amlodipine / Valsartan / Hydrochlorothiazide combination tablets are advised to continue taking their medication and to contact their pharmacist or physician for advice on alternative treatment. The risk of harm to a patient’s health may be higher if the treatment is stopped immediately without any comparable alternative treatment.

Teva Pharmaceuticals USA is notifying its distributors and customers by certified mail and is arranging for return/reimbursement of returned recalled products. Pharmacy distributors and retailers that have product that is being recalled should immediately stop distribution and quarantine any quantities remaining in their control and return the recalled product.

Customers and patients with medical-related questions, information about an Adverse Event or other questions about the Teva products being recalled should contact Teva’s Medical Information by phone at: 888-838-2872, option 3, then, option 4. Live calls are received Monday-Friday, 9:00AM-5:00PM Eastern Time with Voicemail available 24 hours/day, 7 days/week or email [email protected]

Adverse reactions or other problems experienced with the use of the products may also be reported to Teva directly at 888-838-2872 or to the FDA’s MedWatch Adverse Event Reporting program either online, by regular mail or by fax.

A full list of the lots of Teva Pharmaceutical hypertension medications being recalled can be found here on the FDA website.

Valsartan is an angiotensin II receptor antagonist (commonly called an ARB, or angiotensin receptor blocker), that is selective for the type I (AT1) angiotensin receptor. Valsartan is the generic drug name associated with the trade name Diovan by Novartis.

Comparison to ACE Inhibitor Drugs
Valsartan blocks the actions of angiotensin II, which include constricting blood vessels and activating aldosterone, to reduce blood pressure.

Valsartan binds to angiotensin type I receptors (AT1), working as an antagonist. Valsartan’s mechanism of action is different compared to ACE inhibitor drugs, which block the conversion of angiotensin I to angiotensin II. Since valsartan acts at the receptor, it can provide more complete angiotensin II antagonism because angiotensin II is also generated by other enzymes in addition to ACE (angiotensin-converting-enzyme). Also compared to ACE inhibitors (such as lisonpril), valsartan does not inhibit the metabolism of bradykinin, which is an inflammatory mediator that causes vasodilation, reducing blood pressure. Bradykinin dilates blood vessels via the release of prostacyclin, nitric oxide, and Endothelium-Derived Hyperpolarizing Factor. Bradykinin-degrading activity in cells could be inhibited in a concentration-dependent manner by the ACE inhibitors lisinopril, ramiprilat, and captopril, which supports increased vasodilation effects of bradykinin during ACE inhibition treatment.

ACE, is a central component of the renin–angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. ACE or Angiotensin-Converting-Enzyme converts the hormone angiotensin I to the active vasoconstrictor angiotensin II.

ACE indirectly increases blood pressure by causing blood vessels to constrict. ACE inhibitors are widely used as pharmaceutical drugs for treatment of cardiovascular diseases.

Teva Pharmaceutical Industries Ltd (TEVA) is an Israeli multinational pharmaceutical company headquartered in Petah Tikva, Israel, known primarily for generic drugs. Teva is also involved in active pharmaceutical ingredients and proprietary pharmaceuticals. Teva is the largest generic drug manufacturer in the world, and one of the 15 largest pharmaceutical companies worldwide.

SOURCE: Gräfe M1, Bossaller C, Graf K, Auch-Schwelk W, Baumgarten CR, Hildebrandt A, Fleck E. Effect of angiotensin-converting-enzyme inhibition on bradykinin metabolism by vascular endothelial cells. Am J Physiol. 1993 May;264(5 Pt 2):H1493-7.



 facebook … 




Get updates from The Cardinal ALL NEWS FEEDS on Facebook. Just ‘LIKE’ the ‘Arlington Cardinal Page (become a fan of our page). The updates cover all posts and sub-category posts from The Cardinal — You can also limit feeds to specific categories. See all of The Cardinal Facebook fan pages at …

Help fund The Cardinal

CLEAR SKIES?  Weather Data for Monday, December 3rd, 2018

Tags: , , , ,    

IMPORTANT NOTE: All persons referred to as subjects, defendants, offenders or suspects, etc. are presumed to be innocent unless and until proven guilty beyond a reasonable doubt in a court of law.

Try a more powerful search in the box below ... SEARCH BOX PRODUCES RESULTS FOR The Cardinal -- ...
(POWERFUL SEARCH for The Cardinal, which can be expanded on the results page.)

Where background Wikipedia info/photos are used, original work is modified and released under CC-BY-SA.

::: Health, wellness and fitness gifts! ::: Cubs, Sox caps at :::

ARLINGTON HEIGHTS BREAKING NEWS --The Cardinal -- is a breaking news blog with Arlington Heights & Chicagoland emphasis. Early breaking reports may prove to be inaccurate after follow-up investigation, which may or may not be updated in The Cardinal -- For in-depth coverage, please also check the following links for network television, cable news networks and Chicago local media coverage ...

Daily Herald | Daily Herald -- Arlington Heights |
Today's headline videos: FOXNews Video | | Associated Press | The Cardinal
Video LOGO youtube Twitter Arlingtoncards facebook battery status Cardinal Calendar Search Batteries Plus RSS Help ...
All Headlines
crimeblog | fireblog

Comments for
COMMENTS are now available via one or more of our official Facebook pages. Comments no longer appear on the article per se. Please comment on or check the other popular Arlington Cardinal Facebook pages at ...

Anyone having information about serious crime in Arlington Heights should register on and look for the anonymous TIP411 feature, or call Arlington Heights Crime Stoppers at 847-590-STOP (847-590-7867). Callers are guaranteed anonymity and may qualify for a cash reward of up to $1,000. Not a resident of Arlington Heights? Check for availability for your community. | Traffic on Twitter


Weather radar map is provided by

RSS Cardinal Weather Center

  • Current Conditions : 34.5F, Clear - 2:14 PM CST Feb. 19
    Temperature: 34.5°F | Humidity: 48% | Pressure: 30.57in ( Falling) | Conditions: Clear | Wind Direction: SSW | Wind Speed: 0mph
  • Winter Weather Advisory - Expires: 3:00 PM CST
    Winter Weather Advisory for Cook County in effect until 3:00 PM CST on February 20, 2019
  • Today as of Feb. 19 3:39 AM CST
    Today - Partly sunny. Highs around 30. Southwest winds around 5 mph in the morning shifting to the southeast in the afternoon.
  • Wednesday as of Feb. 19 3:39 AM CST
    Wednesday - Light snow and light freezing rain in the morning, then light rain likely in the afternoon. Snow accumulation up to 1 inch. Total snow accumulation 1 to 2 inches. Ice accumulation up to one tenth of an inch. Highs in the mid 30s. East winds 10 to 20 mph in the morning shifting […]
  • Tonight as of Feb. 19 3:39 AM CST
    Tonight - Cloudy. Light snow after midnight. Snow accumulation up to 1 inch. Temperatures nearly steady in the upper 20s. East winds 5 to 10 mph in the evening increasing to 10 to 20 mph after midnight. Near the lake, gusts up to 30 mph after midnight. Chance of precipitation 80 percent.